Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: A population-based cohort study using multiple linked UK electronic health records databases
The Lancet Sep 29, 2019
Strongman H, Gadd S, Matthews A, et al. - Through cohorts of survivors of the 20 most prevalent cancers in people (n = 126,120) who were 18 years or older and alive 12 months following the diagnosis and controls (n = 630,144) without a history of cancer, matched for age, gender, and general practice, experts address the evidence on the risks of specific cardiovascular diseases in survivors of a wide range of cancers gaps. In comparison with that of controls, in survivors of 18 of 20 site-specific cancers, venous thromboembolism risk was raised. HRs decreased over time however continued to be raised more than 5 years following diagnosis. Heightened risks of heart failure or cardiomyopathy in patients following ten of 20 cancers, including hematological, oesophageal, lung, kidney, and ovarian, was noticed. High risks of arrhythmia, pericarditis, coronary artery disease, stroke, and valvular heart disease were also noted for multiple cancers, including hematological malignancies. In patients without former cardiovascular disease and in younger patients, HRs for heart failure or cardiomyopathy and venous thromboembolism were greater. Nevertheless, absolute excess risks were usually greater with progressing age. In individuals who received chemotherapy, elevated risks of these outcomes appeared most proclaimed. Thus, with substantial differences among cancer sites, survivors of most site-specific cancers had progressed medium-term to long-term risk for one or more cardiovascular diseases in comparison with that for the general population.
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