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Mediterranean-style diet in pregnant women with metabolic risk factors (ESTEEM): A pragmatic multicentre randomized trial

PLoS Medicine Aug 07, 2019

Al Wattar BH, Dodds J, Placzek A, et al. - Through a multicentre randomized trial in 5 maternity units (4 in London and 1 in Birmingham) between September 12, 2014, and February 29, 2016, experts evaluated whether a Mediterranean-style diet decreased adverse pregnancy outcomes in high-risk women. A total of 7,950 women were screened and 1,252 were randomized. Women in the intervention arm vs controls consumed more nuts and extra virgin olive oil and increased their consumption of fish, white meat, and pulses and decreased their consumption of red meat, butter, margarine, and cream. No notable decrease in the composite maternal or composite offspring outcomes was noted. An apparent decrease in the odds of gestational diabetes by 35% was observed, although not in other individual components of the composite outcomes. Mothers gained less gestational weight with intervention as that of the control. Between both groups, no variation in any of the other maternal and offspring complications was noted. A marked decrease in gestational diabetes, with no heterogeneity, was observed when findings from the Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes trial with comparable trials using random-effects meta-analysis was pooled in it. In conclusion, no decrease in the overall risk of adverse maternal and offspring complications was discovered with a simple, individualized, Mediterranean-style diet in pregnancy, however, it had the potential to diminish gestational weight gain and the risk of gestational diabetes.
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