Gershon AS, McGihon RE, Thiruchelvam D, et al. - Researchers applied health administrative data to conduct a retrospective cohort study from 2004 to 2016 from Ontario, Canada. This study included adults with chronic obstructive pulmonary disease (COPD) aged 66 years or older who had filled prescriptions for a long-acting muscarinic antagonist or long-acting beta-agonist and inhaled corticosteroid continuously for one year or more. They applied log-binomial regression models to ascertain the risk of medication discontinuation following hospitalization in each medication cohort. Medications were discontinued 1,466 times, over 27,613 hospitalization discharges. It was shown that hospitalization was correlated with an elevated risk of long-acting inhaler discontinuation in an observational study of highly adherent COPD patients. These data imply a likely larger discontinuation problem among fewer adherent patients and should be verified in a prospective cohort of average COPD patients. After discharge, quality improvement efforts should target on safe transitions and patient medication reconciliation.