Torrungruang K, et al. - A cross-sectional study was conducted to examine the associations between periodontitis, systemic inflammation, and glycemic status. The C-reactive protein (CRP), white blood cell count (WBC), and platelet-lymphocyte ratio (PLR) mediated 8%, 13%, and 6% of the association between severe periodontitis and diabetes, respectively. Similar proportions mediated the periodontitis-impaired fasting glucose (IFG) association. Thus, systemic inflammation plays a role in mediating the associations between periodontitis and IFG or diabetes.