Bogorodskaya M, Fitch KV, Lu M, et al. - Given that people with HIV (PWH) who are well treated on antiretroviral therapy remain at increased risk for body composition changes, including increased visceral adipose tissue (VAT) and reduced subcutaneous adipose tissue (SAT), as well as increased cardiovascular disease (CVD), researchers intended to determine if there is an association between adipose compartments and coronary disease among PWH. In total, 148 PWH and 68 uninfected people without CVD were well phenotyped for VAT and SAT via single-section abdominal CT at L4. Coronary artery calcium (CAC) score was evaluated by noncontrast cardiac CT and coronary plaque composition by coronary CT angiography. The increased VAT was significantly associated with an increased presence of plaque and CAC > 0 in the HIV group. In contrast, increased SAT was associated with reduced presence of plaque and reduced CAC > 0 among PWH. Phenotyping fat redistribution by simultaneously quantifying VAT and SAT as independent measures may help identify those PWH at higher risk for CVD.