Chen HC, et al. - In this study performed on patients, enrolled in the CKD program of China Medical University Hospital between July 2004 and Aug 2013, with chronic kidney disease (CKD) stages 3–5 (estimated glomerular filtrate rate (GFR) [eGFR] < 60 mL/min/1.73 m²) not yet on dialysis, researchers assessed the prognostic role of the maximum, the minimum, and the average of GFR decline rate, focusing on a composite of mortality and renal replacement therapy (RRT). Cox proportional hazard regression was used. Overall, 815 patients aged 75 (interquartile range [IQR] 65–82) years with a median follow-up of 5.2 years (IQR 3.9–6.9) were included. Findings revealed the association of the maximum of GFR decline rate with mortality and poor renal outcome in CKD patients, independent of other contributive confounders.