Zeidán-Chuliá F, et al. - Experts collected the in vivo and in silico evidence on the role of matrix metalloproteinase-7 (MMP7) in the interplay between type 2 diabetes mellitus (T2DM) and generalized periodontitis (GP). Findings suggested an association between elevated MMP7 expression in gingival tissues of patients with T2DM/GP and the activation of reactive oxygen species by hyperglycemia. In gingiva, impaired neutrophil transmigration was led by the suppression of MMP7 expression.