Ye X, et al. - In a cohort study, researchers analyzed 262,116 mother-child pairs of Manitoba births to examine the link between maternal antibiotics use during pregnancy and cancer incidence risk in the offspring. They evaluated antibiotics use by mothers in the 6 months before pregnancy and pregnancy periods. Findings revealed no association of antibiotics use during pregnancy with overall cancer (hazard ratio= 1.1, 95% confidence interval 0.9-1.4), leukemias (1.3, 0.9-1.8), or acute lymphocytic leukemia (1.1, 0.7-1.6). By trimester, the link between antibiotics use and overall cancer risk differed, with an HR of 1.5 (1.1-1.9) in the first, 0.8 (0.6-1.0) in the second, and 1.1 (0.8-1.5) in the third trimester. The link between first-trimester exposure and cancer risk needs further research following a better controlling of confounding factors.