Kapustin RV, Chepanov SV, Babakov VN, et al. - Via performing this longitudinal, prospective study, researchers sought to determine serum concentration of leptin, adiponectin, resistin, and MCP-1 in pregnant patients with different types of diabetes mellitus (DM) considering preconception planning and method of DM correction in 11–14th and 30–34th weeks of pregnancy. They included 130 pregnant women in this study and divided them into the following comparison groups: type 1 DM (T1DM, n = 40), type 2 DM (T2DM, n = 35), GDM (n = 40), and the control group (n = 15). The leptin level in the 1st trimester was noted to be highest in T2DM insulin group compared with the control due to gestational age, therefore, its serum concentrations seemed higher in the 3rd trimester in all groups than in healthy patients. They noted direct correlation of leptin levels in the 1st trimester – with women's BMI, newborns’ weight and macrosomia rate and in the 3rd trimester – with OGTT levels, HbA1c, gestational hypertension, and preeclampsia rates. Almost all DM groups showed increased resistin levels in the 1st and 3rd trimesters compared with the control group. Direct positive correlation between resistin and HbA1c, birth weight, and preeclampsia was established in this study. In the 1st trimester, T2DM insulin group had the lowest adiponectin levels compared with T1DM and the control group while in the 3rd trimester, adiponectin levels decreased alongside gestational age in DM patients and all the groups compared with the control group. Negative correlation was observed of adiponectin with BMI, OGTT levels, and preeclampsia rate. Relative to T1DM patients and the control group, T2DM patients seemed to have higher MCP-1 levels in the 1st trimester, whereas decline in MCP-1 was noted in the 3rd trimester, correlating with BMI, preeclampsia and OGTT levels. Based on findings, they suggest that more severe metabolic failures and further disturbances of adipokines expression might explain the development of high rate of adverse perinatal outcomes in diabetic pregnancy.