Jaramillo-Ospina A, Castaño-Moreno E, Muñoz-Muñoz E, et al. - The results showed that maternal obesity is associated with a higher concentration of adiponectin and leptin in their offspring at birth. Researchers found a relevant effect on anthropometrics in male offspring and on leptin in female newborns. There is a need for further studies to assess the extension of these effects in postnatal life.

• A cross-sectional analysis was conducted to assess a total of 221 subsamples of mother-child dyads participating in a cohort study.

• Offspring from mothers with obesity had higher birth weight, a higher proportion of large for gestational age, higher ponderal index, and heavier placentae than offspring from normal-weight mothers.

• Males had significantly higher weight, length, the proportion of large-for-gestational-age newborns, higher weight for length ratio, within the offspring from women with obesity.

• Compared with females, males had more efficient placentas.

• The study found higher adiponectin and leptin in both sexes and higher leptin in female offspring of mothers with obesity after adjusting for birth size.

• They further observed higher IL-12p40 in the offspring of women with MO with no other differences in other cytokines among groups.