HZ Ling, et al. - In this prospective, longitudinal observational study, maternal haemodynamics were compared in women at low and high risk for preterm preeclampsia (PE), and between those at high risk who are randomized to aspirin or placebo. At maternity units in six UK hospitals, researchers assessed women participating in the Aspirin for Prevention of Preterm Pre‐eclampsia (ASPRE) trial. The following three groups of women comprised the study population: low risk for preterm PE (n = 1,362), high risk for preterm PE treated with aspirin (n = 208), and high risk for preterm PE on placebo (n = 220). Women were assessed at their four visits during pregnancy: 11–14, 19–24, 30–34, and 35–37 weeks’ gestation, for blood pressure measures, and for PE and maternal haemodynamics. During pregnancy, the low‐risk group showed the expected changes with an increase in CO and decrease in MAP and PVR, with a quadratic change across gestation and the high‐risk groups showed a declining CO, and higher MAP and PVR. Outcomes thereby suggest a pathological cardiac adaptation to pregnancy in women screened as high risk for preterm PE and occurrence of no alteration in haemodynamic profile in this group in correlation to the prophylactic use of aspirin (150 mg oral daily from the first trimester).