Gibbone E, Wright A, Campos RV, et al. - Researchers analyzed females attending for a routine hospital visit at 19 + 1 to 23 + 3 weeks' gestation, in this prospective observational study, to assess the factors from maternal features and medical history that impact maternal cardiovascular indices as well as to determine if subsequent development of PE could potentially be predicted with the help of maternal cardiovascular indices at 19–23 weeks' gestation, on their own as well as together with maternal factors and the established biomarkers of pre‐eclampsia (PE), including uterine artery pulsatility index (UtA‐PI), mean arterial pressure (MAP), serum placental growth factor (PlGF) and serum soluble fms‐like tyrosine kinase‐1 (sFlt‐1). As per findings, maternal demographic features and elements of medical history known to be related to an elevated risk for subsequent development of PE were identified to have a significant impact on all maternal cardiovascular indices. Peripheral vascular resistance was identified as the only cardiovascular index that was significantly impacted by subsequent development of PE; this was evident post-adjustment for maternal demographic features and medical history. Weak correlations were identified between various cardiovascular indices and MAP multiples of the median (MoM), but none was found to be correlated with MoM values of UtA‐PI, PlGF or sFlt‐1. Overall, information regarding PE pathophysiology is offered by maternal cardiovascular function evaluation but such an evaluation was not beneficial in PE prediction.