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Maternal cardiac assessment at 35 to 37 weeks improves prediction of development of preeclampsia

Hypertension Jul 17, 2020

Garcia-Gonzalez C, Georgiopoulos G, Azim SA, et al. - Differences in maternal cardiac indices at 35+0 to 36+6 weeks’ gestation between women who subsequently developed preeclampsia at term vs those with uncomplicated pregnancy, were determined. In addition, whether cardiac indices offer incremental prognostic value to the available screening algorithm for preeclampsia, was examined. Among 1,602 women with singleton pregnancies who attended for a routine hospital visit at 35+0 to 36+6 weeks’ gestation, 3.12% (50/1602) developed preeclampsia. Mean arterial pressure, systemic vascular resistance and preeclampsia-risk-score were increased among women with preeclampsia, compared with those without. In multivariable analysis, they noted an independent correlation between the incidence of preeclampsia and E/e′ as well as left ventricular mass indexed for body surface area. Risk for developing preeclampsia was higher among women with E/e′ ≥ 7.3 and left ventricular mass indexed for body surface area ≥ 63.2 g/m2, despite low preeclampsia-risk-score < 5%. Findings suggest that raised left ventricular mass and E/e′ offer incremental information to available scoring systems and lead to better stratification of women at risk of developing preeclampsia at term.

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