Krishnaveni GV, Veena SR, Johnson M, et al. - In the present study, the researchers tested the assumption that low plasma vitamin B12 (B12) and high folate and homocysteine concentrations in the mother are correlated with higher hypothalamic–pituitary–adrenal axis (cortisol) and cardiovascular responses during the Trier Social Stress Test for Children (TSST-C) in an Indian birth cohort. Participants in the study were adolescents (n = 264; mean age: 13.6 years), whose mothers’ plasma B12, folate and total homocysteine concentrations were measured during pregnancy, completed 5-minutes each of public speaking and mental arithmetic tasks in front of 2 unfamiliar “judges” (TSST-C). Findings suggested an association of maternal low B12 status (plasma B12 < 150 pmol/L) with greater cortisol responses to stress in the offspring. Higher homocysteine concentrations were linked to greater offspring heart rate response. There were nonsignificant connections between higher maternal folate concentrations and offspring total peripheral resistance response after adjustment for multiple comparisons. The results indicate that maternal 1-carbon nutritional status may have consequences for long-term programming of offspring neuroendocrine stress responses.