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Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

Thorax Mar 01, 2021

de Gouveia Belinelo P, Collison AM, Murphy VE, et al. - Researchers here examined correlation, if any, between maternal asthma and lung function in early life. They combined data on lung function determined at 5–6 weeks of age from two large birth cohorts: the Bern Infant Lung Development (BILD) and the Australian Breathing for Life Trial (BLT) birth cohorts conducted at three study sites (Bern, Switzerland; Newcastle and Sydney, Australia). Mothers of all 406 BLT infants were reported to have asthma in pregnancy, while 193 of the 213 (91%) BILD infants were born to mothers without asthma. FiTime to reach peak tidal expiratory flow as a percentage of total expiratory time(tPTEF:tE%) was identified to be negatively affected by a significant interaction between maternal asthma and male gender. Overall findings suggest correlation of maternal asthma with lower lung function in male babies, which may have lifelong implications on their lung function trajectories and future risk of wheezing and asthma.

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