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Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study

PLoS Medicine Mar 13, 2020

Lund-Blix MA, Tapia G, Mårild K, et al. - This study intended to evaluate the correlation between maternal and child intake of gluten and risk of type 1 diabetes in children. A total of 86,306 children were included in an observational nationwide cohort study, the Norwegian Mother and Child Cohort Study (MoBa), with recruitment from 1999 to 2008 and with follow-up time to April 15, 2018. They applied registration of type 1 diabetes in the Norwegian childhood diabetes registry as the outcome. A Cox proportional hazard regression was carried out to evaluate hazard ratios (HRs) for the mother’s intake of gluten up to week 22 of pregnancy and offspring gluten intake when the child was 18 months old. The outcomes display that, while the mother’s intake of gluten in pregnancy was not correlated with type 1 diabetes, a higher intake of gluten by the child at an early age may give a higher risk of type 1 diabetes.
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