Suvakov S, et al. - In this prospective study, researchers investigated the prognostic role of a model comprising glutathione S-transferases (GST, well-established antioxidants) gene polymorphisms, oxidative damage byproducts and cell adhesion markers, in end-stage renal disease (ESRD) patient survival. Overall 199 patients with ESRD on haemodialysis were included. A significant association of GSTM1-null genotype with shorter overall and cardiovascular-specific survival was reported. With regard to overall and cardiovascular survival, a significant predictive role of oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) was shown. When a scoring model including the combination of 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/­sVCAM-1/sICAM-1) was used, patients with the highest score demonstrated a significantly shorter overall and cardiovascular survival. Overall, a new panel of biomarkers for predicting survival in ESRD patients was discovered in this study. Better monitoring as well stratification into suitable treatment groups could be done using this biomarker signature.