Margossian R, et al. - Given the correlation of disordered bone mineral metabolism and low vitamin D concentrations with cardiovascular abnormalities, researchers examined HIV-infected youth regarding this relationship. The participants were perinatally HIV-infected (PHIV) and perinatally HIV-exposed but uninfected (PHEU) youth enrolled in the Adolescent Master Protocol, a Pediatric HIV/AIDS Cohort Study network study including 14 US sites. They identified 485 participants (305 PHIV and 180 PHEU) who had echocardiograms and bone mineralization measures. Findings revealed that 25-hydroxy-vitamin D, parathyroid hormone, and fibroblast growth factor-23 correlated with both structural and functional cardiac parameters. both low 25-OHD and elevated PTH were linked with lower mean left ventricular mass z-scores; increased PTH was linked with higher mean fractional shortening z-scores, following adjustments for HIV status and demographic covariates. Though differences were more distinct in PHEU participants vs PHIV participants, those with low 25-OHD also had slightly increased mean LV end-systolic wall stress z-scores. Results seen to infer that bone mineral metabolism is associated with cardiac status.