Venø SK, et al. - In this investigation, researchers tested the premise that total marine n-3 polyunsaturated fatty acids (PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in diet and adipose tissue (biomarkers of long-term intake and endogenous exposure), are inversely linked to ischemic stroke risk and its subtypes. Study participants included 57,053 enrollees of the Diet, Cancer and Health cohort (aged 50-65 years). A full 1,879 participants had an ischemic stroke during 13.5 years of follow-up. Apart from cardioembolism, EPA was associated with lower risks of most types of ischemic stroke, whereas inconsistent findings were observed for total marine n-3 PUFA and DHA. The EPA content in adipose tissue was inversely linked to small-vessel occlusion.