Mohler JL, et al. - Authors prospectively assessed the effectiveness and morbidity in a contemporary multi-institutional salvage radical prostatectomy (SRP) series. Forty-one men with biopsy-proven recurrent prostate cancer following ≥ 60c Gy radiation as primary treatment for cT₁-₂N_XM₀ disease were enrolled between 1997 and 2006. Twenty-four men had had external beam radiotherapy, 11 brachytherapy, and six both. Results demonstrated 51, 39, and 33% to be the 2-, 5- and 10-year biochemical progression-free survival (BPFS) rates respectively. The 2-, 5- and 10-year OS rates were 100, 89, and 52%, respectively, at median follow-up 91 months. Out of 38 evaluable patients, 17 (45%) suffered urinary incontinence (≥ 3 pads/day) before to SRP; 88% reported urinary incontinence at 6 months, 85% at 12 months, and 63% at 24 months after SRP. Additionally, 37% of men reported impotence before to SRP, while 78% reported impotence at 6 months, 82% at 12 months, and 44% at 24 months following SRP. Significant peri-operative complication rates remain prevalent with modern surgical techniques, but durable oncologic control can still be achieved with SRP in carefully selected patients.