Gaynor SC, Monson ET, Gaine ME, et al. - In view of their previous genome-wide association study (GWAS) of attempted suicide within bipolar disorder implicating common variation in the 2p25 region primarily in males, researchers further investigated the correlation between the 2p25 region and attempted suicide. They sequenced the entire 350kb 2p25 region in 476 bipolar suicide attempters and 473 bipolar non-attempters utilizing targeted next-generation sequencing. The 2p25 region was identified to have 4,681 variants in this fine-mapping project. Conducting both gene-level and individual-variant tests on the sequencing results, they recognized 375 variants that were nonsignificant and three common variants that had a significant association with attempted suicide in males. They observed a strong linkage disequilibrium between these three variants and the top variant from their GWAS. Further, Based on publicly available brain expression databases, the top five variants are also prophesied expression quantitative trait loci (eQTL) for three genes in the 2p25 region. The sequencing and eQTL data imply that the association of the 2p25 region with suicide involves these three genes – SH3YL1, ACP1, and FAM150B – and three additional pathways – androgen receptor, Wnt signaling, and glutamatergic/GABAergic signaling. This study thereby yielded evidence further supporting the association of the 2p25 region with attempted suicide in males and suggesting several candidate genes and pathways that should be further investigated for their role in suicidal behavior.