Ramiro-Cortijo D, de la Calle M, Böger R, et al. - Given that male fetal gender is related to higher rates of materno-fetal complications and mechanisms implicated in obstetric complications include inflammation and inadequate vasoactive responses, and that potential predictive biomarkers are changes in maternal plasma cytokine profile as well as nitric oxide (NO) metabolites, therefore, researchers sought to determine the impact of fetal gender on these parameters in this prospective, observational study with 85 healthy pregnant women with singleton pregnancies in the first trimester of pregnancy. Experts obtained a blood sample at the tenth week of gestation, and plasma samples were evaluated for cytokines and NO metabolites. Findings revealed that maternal plasma cytokine profile and NO in early pregnancy were impacted by fetal gender. A worse capacity to counteract an inflammatory response may be seen in women with a male fetus. Better vasodilator capacity may be shown by them, but the occurrence of a higher nitrosative damage may be noted in the presence of an oxidative environment. The requirement to include gender as variable in predictive models was strengthened by these revelations.