Londero LS, et al. - Via performing a nationwide study, researchers sought to determine the incidence and geographical distribution of vascular services and major amputations in patients with the peripheral arterial disease in Denmark. Linking data from population-based healthcare and administrative databases, they identified 13,075 first-time major amputations during 1997–2014. A decrease in the incidence rate from 41.67 per 100,000 citizens ≥ 50 years of age in 1997–2002, to 32.53 in 2009–2014 was observed, but with municipal differences. In parallel, an increase in revascularisations was observed from 166.63 per 100,000 citizens ≥ 50 years of age in 1997–2002, to 239.05 in 2009–2014. An increase in the percentage of patients evaluated by a vascular surgeon within a year prior to amputation was observed, from 23.7% to 31.3%, while there was no increase in the proportion having revascularisation within a year prior to amputation. As per multivariable logistic regression analysis, a higher risk of undergoing amputation without prior revascularization was observed in correlation with diabetes mellitus (OR 1.28), stroke (OR 1.66), coronary heart disease (OR 1.25), and renal disease (OR 1.31). These findings suggest that despite a decrease in the incidence of major amputations with an increase in general cardiovascular prevention and revascularisation rates, there were only a few patients who had revascularisation prior to amputation, leaving room for improvements.