MAFLD identifies patients with significant hepatic fibrosis better than NAFLD
Liver International Dec 06, 2020
Yamamura S, Eslam M, Kawaguchi T, et al. - In this investigation involving 765 Japanese patients with fatty liver (median age 54 years), researchers sought to compare the diagnostic accuracy of the metabolic associated fatty liver disease (MAFLD) definition compared to the existing NAFLD criteria to identify patients with significant fibrosis and to describe the effect of mild alcohol intake. It was noted that 79.6% and 70.7% of the 765 patients were diagnosed with MAFLD and NAFLD, respectively. In MAFLD, liver stiffness was higher relative to NAFLD. In logistic regression, MAFLD, alcohol intake, and NAFLD were independently linked to significant fibrosis. The MAFLD description best defines a group with fatty liver and significant fibrosis evaluated by non‐invasive tests. In addition, even mild alcohol consumption is linked with worsening of hepatic fibrosis measures in patients with MAFLD.
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