Xie N, Tan Y, Liu S, et al. - In the present study, the researchers sought to evaluate the alterations of macular vessel density (VD), as well as other factors, in diabetic patients utilizing swept-source optical coherence tomography angiography in a large-scale sample from Chinese communities. Patients with type 2 diabetes with no history of ocular treatment were enlisted from 2017 to 2018. Using univariate and multivariate linear regression, they analyzed the association of parafoveal vessel density (PVD) with diabetic retinopathy (DR), diabetic macular edema (DME), HbA1c, and other factors. In total, 919 patients were included in the final statistical analysis.  Reduced PVD was correlated independently with more severe DR, older age, higher HbA1c level, and DME presence. Such results indicate that macular vessel alterations in DR in the longitudinal studies require further study.