Fard MA, et al. - Patients with primary open-angle glaucoma (POAG) and atrophic nonarteritic anterior ischemic optic neuropathy (NAION) were evaluated for macular vasculature. In this cross-sectional study, optical coherence tomography angiography (OCT-A) was used for imaging 37 eyes with moderate and advanced POAG, 19 eyes with atrophic NAION, and 40 eyes of normal individuals. As per linear models, no differences were evident in averaged peripapillary retinal nerve fiber layer and macular ganglion cell complex between NAION and POAG eyes, however, both of these were significantly thinner than control eyes. In NAION and POAG with similar retinal nerve fiber layer and macular damage, less involvement of superficial and deep vascular plexus in NAION vs POAG was evident in macular OCT-A. This suggests the possibility of a primary vascular insult in addition to secondary vascular damage due to ganglion cell damage.