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Lymphocytoma cutis (cutaneous B-cell pseudolymphoma): Study of 102 cases with emphasis on the histological characteristics and immunohistochemistry of the miliarial type

International Journal of Dermatology Sep 23, 2021

Villalobos-Ayala RA, Espinoza-Gurrola AA, Guevara-Gutiérrez E, et al. - According to this retrospective study, the significance of lymphocytoma cutis (LC) stems from the fact that it is clinically and histopathologically similar to cutaneous lymphoma and that it is an uncommon entity, with its miliarial variant much rarer. This research focuses on the clinical-histological aspects of LC as well as its immunohistochemistry.

  • Patients with LC were included if they had both a clinical and histopathological diagnosis.

  • There were 102 patients diagnosed with LC over an 18-year period: 72 (71%) were females, the median age was 45 years, the median evolution time was 4 months, and the face was the most commonly affected location in 81 (79%) cases.

  • Localized-type LC was found in 88 (86%) of the patients, while the miliarial type was seen in 14 (14%) of the cases.

  • Surgery was the most prevalent treatment, used in 32 (31%) of the patients, all of whom had localized type.

  • Corticosteroids were the most commonly used treatment for miliarial-type LC in five (36%), the predominant histopathological pattern was nodular in ten (71%), and immunohistochemistry was performed in 11 (79%), where all were positive for CD20 with polyclonality to kappa and lambda light chains.

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