Martini K, Ottilinger T, Serrallach B, et al. - Six radiologists with various degrees of clinical experience in radiology, rated 100 submillisievert CT chest studies as either negative screening finding (no nodules, benign nodules, nodules < 5 mm), indeterminate finding (nodules 5-10 mm), positive finding (nodules > 10 mm) in order to evaluate the interreader variability of submillisievert CT for lung cancer screening in radiologists with different experience levels. Between all readers, the overall interobserver agreement was moderate. In 57 individuals, all radiologists settled on the distinction of negative and indeterminate/positive finding. In 64 cases disagreement between readers resulted in distict nodule classification. In eight cases some readers classified the nodule as benign, while others scored the case as positive. In all, disagreement in nodule classification was mostly because of failure in recognition of target lesion (n = 40), distinct lesion measurement (n = 44) or distinct classification (n = 26). Thus, this study, for the identification and classification of pulmonary nodules in submillisievert CT, exhibited substantial interobserver variability. This reflects the significance for cautious standardization of screening programs with the objective of harmonizing efforts of involved radiologists across various institutions via defining and warranting quality standards.