Zhang L, Yip R, Jirapatnakul A, et al. - Longer intervals between screening rounds for individuals who are at lower risk of lung cancer would reduce the total number of annual rounds and increase the efficiency of screening, so researchers here examined whether eligible participants in a program of LDCT screening who are at lower risk of lung cancer have less aggressive cancers than those at higher risk. From the I-ELCAP database, they retrospectively identified 118 participants who had been screened using HIPAA-compliant protocols and had solid lung cancers diagnosed on an annual round of screening, 7–18 months following the previous round. Significant differences were observed concerning volume doubling time (VDTs) by cell-type; median VDT for small cell was 34.0 days, followed by other cell-types (61.8 days), squamous-cell (73.3 days), and adenocarcinoma (135.7 days). They identified no correlation between lung cancer risk and tumor stage and VDT. No significant difference was observed in VDT and tumor stage by age or pack-years of smoking. The findings overall yielded no evidence for determining intervals between repeat screenings using risk-based characteristics.