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Lung cancer patients with COVID-19 in Spain: GRAVID study

Lung Cancer May 17, 2021

Provencio M, Gallego JMM, Calles A, et al. - Researchers undertook this prospective observational study (GRAVID study) to determine the clinical features, results, as well as predictors of poor outcome in patients suffering from lung cancer and coronavirus disease 2019 (COVID-19). They analyzed 447 patients with a mean age of 67.1 ± 9.8 years, selected from 65 Spanish hospitals. Most of them were men (74.3%) and current/former smokers (85.7%). The most frequent type of cancer (84.5%) was non-small cell lung cancer. About 60% of patients were undergoing anticancer treatment. Hospitalization occurred in 350 (78.3%) patients for a mean of 13.4 ± 11.4 days, admission to ICU occurred in 9 (2.0%) and deaths occurred in 146 (32.7%). COVID-19 severity was shown to correlate to higher mortality, ICU admission, and mechanical ventilation rates. Patients who received corticosteroids during hospitalization were found to have higher mortality rate, while there was no link of anticancer therapy with an elevated risk of hospitalization or death. There is a need for tailored approaches in order to offer effective cancer management while reducing the risk of exposure to severe acute respiratory syndrome coronavirus 2.

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