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Lower serum beta-2 microglobulin levels are associated with worse survival in incident peritoneal dialysis patients

Nephrology Dialysis Transplantation Jan 10, 2019

Chang TI, et al. - In a 10-year cohort of 725 incident peritoneal dialysis (PD) patients who were maintained on dialysis between January 2006 and December 2011, researchers assessed the association of time-updated and baseline serum beta-2 microglobulin (B2M) levels with mortality by using Cox proportional hazards regression analyses. They reported 258 (35.4%) deaths, 106 (14.6%) and 86 (11.9%) attributed to cardiovascular and infectious causes, respectively, during a median follow-up of 38 months. Findings revealed an independent association of lower B2M levels with overall and infectious mortality in incident PD patients. They also noted that, malnutrition, inflammation and residual renal function (RRF) could potentially modified these associations.
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