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Lower anti-mullerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesity

American Journal of Obstetrics and Gynecology Oct 11, 2019

Vitek W, Sun F, Baker VL, et al. - Researchers examined how lower anti-mullerian hormone in women with obesity undergoing in vitro fertilization influence oocyte yield and live-birth rate. From the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database, they assessed a retrospective cohort of 13,316 women with obesity and 16,579 women with normal BMI who were undergoing their first autologous IVF with fresh transfers between 2012 and 2014. The analysis revealed that women with obesity, vs those with normal BMI, were older (36.0 ± 4.8 vs 35.5 ± 4.8), had lower anti-mullerian hormone (1.8 ± 2.0 ng/ml vs 2.1 ± 2.0 ng/ml) and fewer oocytes retrieved (11.9 ± 7.3 vs 12.8 ± 7.7). These findings suggest that lower anti-mullerian hormone appears to reflect lower ovarian reserve in infertile women with obesity. They identified no association of lower anti-mullerian hormone with a lower live birth rate among women with obesity despite having lower oocyte yield.
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