Albrecht E, et al. - Whether high-dose intraoperative opioids vs a low-dose regimen in patients under general anaesthesia contribute to increased postoperative pain and hyperalgesia was investigated in this meta-analysis of 27 randomised controlled trials with 1,630 patients. This study included only those trials that reported pain outcomes and compared two different dosages of the same intraoperative opioid in patients under general anaesthesia. Pain score (analogue scale,0-10) at 24 postoperative hours was considered as the primary outcome. The high-dose group exhibited an increase in the pain score at rest at 24 postoperative hours as well as significantly higher pain score and cumulative intravenous morphine equivalents consumed at 2 postoperative hours. This study generates low certainty of proof that high-dose intraoperative opioid use vs a low-dose regimen increases pain scores in the postoperative period.