Kim MH, Kim IB, Lee J, et al. - Recent reports have suggested significant contributions of somatic mutations arising from the brain to neurodevelopmental disorders, including childhood intractable epilepsy and cortical malformations, so researchers here examined implications of brain somatic mutations in schizophrenia (SCZ). Deep whole exome sequencing (average read depth > 550x) of matched dorsolateral prefrontal cortex and peripheral tissues from 27 SCZ and 31 age-matched control individuals was done, resulting in an average of 4.9 and 5.6 somatic mutations per exome per brain in SCZ and control individuals, respectively. Although SCZ and controls did not differ significantly in mutational profiles, such as the number and type of mutations, somatic mutations in SCZ brains were significantly enriched for SCZ-related pathways, including dopamine receptor, glutamate receptor, and long-term potentiation pathways. Overall these findings suggest a relationship between brain somatic mutations and the pathogenesis of SCZ.