Pedersen KM, Çolak Y, Bojesen SE, et al. - In this investigation involving 116,728 people, experts aspired to explore whether low high-density lipoprotein (HDL) levels are correlated with increased risk of cancer. People from two population-based cohorts, the Copenhagen General Population Study (2003–2015, N = 107,341), and the Copenhagen City Heart Study (1991–1994, N = 9,387) were followed prospectively until end of 2016 to evaluate low plasma HDL cholesterol and apolipoprotein A1 as risk factors for cancer utilizing Cox proportional hazard regression. Among 27 cancer types, increased risk of multiple myeloma, myeloproliferative neoplasm, non-Hodgkin lymphoma, breast cancer, lung cancer, and nervous system cancer were associated with low HDL cholesterol and/or apolipoprotein A1. Low HDL levels have been related to increased risk of several cancers. Increased incidence was most pronounced for hematological and nervous system cancer and, to a lesser degree, for breast and respiratory cancer.