Lund AV, Thostrup AH, Frithioff-Bøjsøe C, et al. - Researchers investigated if there is a link between low-grade inflammation and cardiometabolic risk among Danish children, independent of degree of adiposity. They also determined the worth of combining multiple inflammation markers to define very-high cardiometabolic risk profiles. Applying a cross-sectional study design, experts analyzed 2,192 children and adolescents aged 6-18 years from an obesity clinic cohort and a population-based cohort. They found high sensitivity C-reactive protein > 0.57-9.98 mg/L (mid/upper tertile) was related to ∼2-fold higher odds of dyslipidemia as well as hepatic steatosis (vs lower tertile) for girls. For both genders, 2.5-fold higher odds of insulin resistance were reported in relation to white blood cells > 7.0-12.4 109/L (upper tertile). The most severe cardiometabolic risk profile was shown by children having multiple inflammation markers in the high-normal range. Overall, findings revealed the existence of a link between low-grade inflammation and cardiometabolic risk in children independent of degree of adiposity. The observed links differed with gender and inflammatory marker measured. A very-high-risk subgroup of children with overweight/obesity was identified by combining multiple low-grade inflammation markers, which may hold clinical value.