Davis-Porada J, Kim MY, Guerra MM, et al. - This study was carried out to ascertain predictors of flares during and after pregnancy in systemic lupus erythematosus (SLE) individuals with inactive or stable disease activity during the first trimester and to characterize and estimate the frequency of post-partum flares in these individuals. Researchers designed a multicenter, prospective PROMISSE (predictors of pregnancy outcome: biomarkers in antiphospholipid antibody syndrome and systemic lupus erythematosus) study to analyze SLE patients for flares during and after pregnancy using the SELENA-SLEDAI Flare Index. They analyzed flares during pregnancy in all 384 individuals and post-partum flares in 234 individuals with study visits 2–6 months post-partum. Logistic regression models were performed to distinguish independent risk factors for flare. The data indicated that lupus disease flares during and after pregnancy are typically mild and occur at similar rates in individuals with inactive or stable mild disease activity at the time of conception. At baseline, flares during pregnancy are prognosticated by the individuals’ age and clinical and serological activity.