Holm PM, et al. - A patient-blinded, parallel-group randomized controlled trial was designed to explore the impacts of lower limb strength training in addition to neuromuscular exercise and education compared to neuromuscular exercise and education alone on self-reported physical function in patients with knee osteoarthritis (KOA). This study recruited a total of 90 patients in secondary care with radiographic and symptomatic KOA, ineligible for knee replacement. Primary endpoint included difference between-group on the subscale activities of daily living from the Knee Injury and Osteoarthritis Outcome Score at 12 weeks. The KOOS symptoms, pain, function during sport and recreation, and quality of life, 40 m walk, stair climb, leg extension power, EuroQol-5D-5L, pain medication usage, and adverse events were considered as secondary endpoints. Applying a low-dose method, the addition of lower-limb strength training, to neuromuscular exercise and education carried no additional advantages on self-reported physical function or on most secondary outcomes. Similar improvements were found in both groups at 12-week follow-up. Therefore, in the group of KOA patients, the current low-dose strength training technique served no additional clinical value.