Mueller C, et al. - Via this single-blind, placebo-controlled trial, researchers sought to determine the effectiveness of dextromethorphan (DXM) in relieving fibromyalgia (FM)-associated symptoms. Forteen women with FM were provided a placebo for 5 weeks, followed by 20 mg DXM for 10 weeks, while providing daily symptom reports on a 0– 100 scale. The patients well tolerated DXM, and high treatment adherence was observed. Outcomes, however, indicated no strong clinical effect of DXM at the 20mg/day dosage.