Van Nest DS, Clarkson S, Chisari E, et al. - This study was undertaken to investigate whether aspirin, when applied as venous thromboembolism prophylaxis, influenced the rate of heterotopic ossification (HO) formation following total joint arthroplasty (TJA). Between January 2016 and June 2018, researchers analyzed a longitudinally maintained database to distinguish all patients who had undergone primary total hip arthroplasty (THA) or total knee arthroplasty (TKA) for osteoarthritis with at least 3-month radiographic follow-up. For analysis, 1,238 THAs and 1,051 TKAs were included. They reviewed radiographs and HO formation graded according to the Brooker classification. They obtained patient demographic and venous thromboembolism (VTE) prophylaxis data and reviewed them for accuracy. The effect of ASA on HO formation was assessed by performing univariate and multivariate analysis. For VTE prophylaxis, individuals undergoing primary TJA receiving aspirin were less likely to develop HO in comparison with individuals who were administered non-aspirin VTE prophylaxis.