Lee C, Park JT, Kang EW, et al. - In chronic kidney disease (CKD), a graded association between low-density lipoprotein cholesterol (LDL-C) and the risk of adverse cardiovascular outcome was identified. LDL-C <70 mg/dL was associated with the lowest risk, indicating that a lower LDL-C target may be acceptable.

• This study involved 1,886 patients from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD).

• Extended major cardiovascular events (eMACEs) (primary outcome) and all-cause mortality, and CKD progression (secondary outcomes) were assessed.

• For LDL-C categories of 70–99, 100–129, and ≥130 mg/dL, the estimated hazard ratios were 2.06, 2.79, and 4.10, respectively, relative to LDL-C <70mg/dL.

• Renal function influenced the predictive performance of LDL-C for eMACEs.

• Significantly higher risks of CKD progression were found in relation to higher LDL-C levels.

• However, LDL-C level was not related to all-cause mortality.