Tagal V, Roth MG., et al. - Given that polyploid giant cancer cells (PGCC) are common in tumors but there is a lack of knowledge regarding the molecular mechanisms that cause these cells to form, therefore, researchers explored this topic in this study and found that Aurora kinases represent synergistic determinants of a switch from the proliferative cell cycle to polyploid growth and multinucleation in lung cancer cell lines. The uniform growth of lung cancer cells into multinucleated polyploid giant cancer cells was seen when Aurora kinases were inhibited together. An endoreplication was adopted by these cells, wherein the genome replicates, mitosis is omitted, and cells grow in size. As a result, a safe growth of such cells continued in the presence of antimitotic agents. Experts noted re-entry of these PGCC into the proliferative cell cycle as well as their growth in cell number when treatment was stopped. Therefore, it was inferred that PGCC formation might be a fundamental cellular response to Aurora kinase inhibitors and likely represent a contributor to therapy resistance or tumor relapse.