Colan SD, et al. - This study was intended to investigate the frequency and longitudinal variation in the presence and severity of echocardiographically documented valvular regurgitation (VR) in healthy children free of evidence of heart disease. Researchers tested the presence of VR was documented on each of the four valves, and the severity of regurgitation as the body surface area (BSA)-adjusted width of the vena contracta on each of two sequential echocardiograms in healthy children free of clinical and echocardiographic evidence of heart disease. A total of 200 children ages 10.0 ± 4.5 years were included in the study. The study's found substantial temporal variation in the presence and severity of tricuspid and pulmonary VR in healthy children with no evidence of heart disease. In healthy children, the prevalence of mitral and aortic VR is lower, but temporal change is also recorded for these valves. Moreover, the data of new-onset echocardiographic trace or mild VR cannot be hypothesized to represent incident valve pathology.