Bingham KS, DiazMartinez J, Green R, et al. - Findings suggested an association of depression and anxiety symptoms in SLE patients with cognitive dimension incorporating memory, executive function and complex processing speed in a stable manner across one year. Many people with cognitive impairment are clinically depressed and anxious.

• A total of 301 SLE patients were included in the study.

• Anxiety and depression and neuropsychological performance remained steady throughout time.

• A factor analysis revealed two factors that accounted for 42.2% of the variance in neuropsychological performance.

• The first dimension (33.1% of the variance) was mostly comprised of complex cognitive tests measuring executive function, verbal, visual, and working memory, and complex processing speed.

• The second component (9.1% of the variation) mostly included assessments of simple information processing speed or motor dexterity.

• The first cognitive dimension was consistently connected to anxiety and depression scores.

• There was significant overlap among persons identified as having cognitive impairment, anxiety, or depression.