Tollisen A, et al. - With measures of juvenile idiopathic arthritis (JIA) disease activity, physical functioning, pain, fatigue, and well-being, a total of 96 individuals with JIA were evaluated within 18 months of diagnosis and every 6 months for the next 3 years between 1995–2003 in order to define the longitudinal health status from childhood to adulthood in individuals with JIA, contrast outcomes following 19 years with those of controls, and recognize early predictors of physical functioning, pain, and physical health-related quality of life (HRQOL). Physical disability got better and the proportion of individuals reporting the best possible well-being progressed, during the first 3 years, while pain and fatigue did not alter. Following 19 years, in patients vs controls, worse pain and physical HRQOL was observed. Pain, active joints, and physical disability during the first 3 years were correlated with more disability and pain and worse physical HRQOL following 19 years. Hence, individuals with JIA reported comparable physical functioning, well-being, and pain at 3- and 19-year followups, though, more fatigue following 19 years were reported. moreover, individuals also had worse health status in comparison with controls following 19 years. Early predictors of unfavorable outcomes were pain, active joints, and physical disability.