Slaven SE, Dey D, Yow BG, et al. - This study was intended to examine changes in serum markers of bone turnover across multiple decades in osteoporotic women compared with nonosteoporotic controls, to ascertain their utility as potential predictors for osteoporosis. Researchers collected serum samples from 20 women given the diagnosis of osteoporosis after age 46 years and 20 age-matched women with normal bone mineral density from 4-time points in their life (ages 25–31, 32–38, 39–45, and 46–60 years). Using commercially available arrays and kits, serum levels of bone turnover markers (propeptide of type I collagen, parathyroid hormone, bone-specific alkaline phosphatase, osteocalcin, C-terminal telopeptide of type I collagen, sclerostin, osteoprotegerin, osteopontin, and 25-OH vitamin D) were assessed. It has been considered that serum markers of bone turnover may be applied to calculate the likelihood of osteoporosis development in individuals over time. This information may be used to identify patients at risk for developing low bone mineral density long before traditional screening would ostensibly take place, although prospective validation is necessary before recommending widespread clinical use.