Guerreiro V, Neves JS, Salazar D, et al. - Researchers examined 1,837 morbidly obese patients (females, 85%; age, 42.5 ± 10.6 years; BMI, 44.0 ± 5.8) who underwent bariatric surgery (Roux-en-Y gastric bypass [RYGB], laparoscopic sleeve gastrectomy [LSG], and laparoscopic adjustable gastric band [LAGB]) in order to appraise long-term differences in weight loss (WL) between different surgical techniques and the impact of each surgical technique on metabolic parameters (type 2 diabetes mellitus [T2DM], dyslipidemia,hypertension, and metabolic syndrome). Further, they sought how baseline clinical characteristics affect WL and the evolution of metabolic syndrome (MetS) components. For RYGB, LSG, and LAGB, the mean percentage of WL, respectively, was 32.9 ± 8.7, 29.8 ± 9.8, and 16.2 ± 9.6 at 12 months and 30.6 ± 9.1, 22.7 ± 10.0, and 15.8 ± 10.8 at 48 months, even after adjustment for baseline weight, BMI, age, and gender. Women vs men had more WL during the first 36 months; older patients vs younger ones had less WL, except at 48 months. Patients with T2DM vs without had less WL after adjustment (gender, age, and surgical technique) during the same period. Patients with hypertension had less WL at 12 months and MetS at 24 months relative to those without these comorbidities. No significant difference was evident concerning the presence of dyslipidemia in WL. For MetS resolution, better results were achieved in the RYGB group. Based on the findings, they conclude that the highest WL and MetS resolution is achieved in correlation to undergoing RYGB.