Kocarnik JM et al. - In the current study it was shown that weight loss 5 years after a diagnosis of CRC was  associated with decreased long-term survival.

Methods
CRC patients were identified through 4 population-based cancer registry sites.
CRC patients were enrolled within 2 years of diagnosis and reported their baseline height and weight.
Follow-up questionnaires were distributed 5 years after diagnosis. 

Results
Of 2049 patients, 53% reported higher (median, 5 kg), 12% reported no change, or 35% reported lower (median, 4 kg) weight.
During a median follow-up of 5.1 years, 344 patients died.
Long-term weight loss (per 5 kg) was associated with poorer overall survival (HR, 1.13) and CRC-specific survival (HR, 1.25).
Relative weight loss (greater than 5% vs. less than or equal to 5% change), BMI reduction (per 1 unit), or BMI category change (overweight-to-normal vs. remaining overweight) was associated with lower survival.