Sanchez-Ramirez C, et al. - In a mixed intensive care unit (ICU) with a high endemic level of multidrug-resistant bacteria (MDRB), researchers assessed the efficacy of long-term use of selective digestive tract decontamination (SDD) in attenuating intensive care unit (ICU)-acquired infection and antibiotic consumption while decreasing colistin-, tobramycin-, and most of the antibiotic-resistant colonization rates. They found that in an ICU setting with a high level of resistance, the observed benefits of 4-year SDD treatment included clinically relevant reductions of MDRB-induced infections, with low rates of colistin- and tobramycin-resistant colonization as well as with nonsignificant increasing rate of ICU colonization resistance by 1000 days, adjusted by the rate of resistances at ICU admission. SDD resulted in significant lowering of ventilator-associated pneumonia and secondary bloodstream infection rates. Notably, antimicrobial consumption was also decreased.