Alqahtani S, et al. - Researchers retrospectively reviewed drug overdose out-of-hospital cardiac arrests (OHCA) from the Victorian Ambulance Cardiac Arrest Registry in order to assess the long-term trends in the incidence and outcomes of drug overdose OHCA. The analysis revealed the incidence of emergency medical services (EMS)-attended and EMS-treated cases of 5.8 and 2.0 per 100,000 person-years, respectively; no significant changes in trend over time was evident. Findings revealed increase in return of spontaneous circulation from 23% to 34% (p for trend = 0.001), event survival from 23% to 30% (p for trend = 0.007), and survival to hospital discharge from 4% to 13% (p for trend = 0.03). Independent correlates of survival were age, arrest witnessed by bystander or EMS, initial shockable rhythm or pulseless electrical activity, intubation, epinephrine and sodium bicarbonate administration. Among the 12-month survivors, 50% of the responders had good functional recovery, and few had severe problems with mobility, self-care, daily activity, pain, and anxiety/depression. These findings suggest a significant improvement in the rates of survival despite no change in the incidence of drug overdose OHCA from 2000 to 2017.